Preimplantation HLA Testing

Preimplantation HLA testing.

CONTEXT Preimplantation genetic diagnosis (PGD) has become an option for couples for whom termination of an affected pregnancy identified by traditional prenatal diagnosis is unacceptable and is applicable to indications beyond those of prenatal diagnosis, such as HLA matching to affected siblings to provide stem cell transplantation. OBJECTIVE To describe preimplantation HLA typing, not invo...

Preimplantation HLA Typing

It has been more than ten years since the first Human Leukocyte Antigen (HLA) matching for Fanconi anemia was reported, allowing successful haemopoietic reconstitution in affected sibling by transplantation of stem cells obtained from HLA-matched offspring (Verlinsky et al., 2000; Verlinsky et al., 2001). Preimplantation Genetic Diagnosis (PGD) in combination with HLA matching is being used to ...

Preimplantation Genetic Testing

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Preimplantation Genetic Testing

Preimplantation genetic testing (PGT) involves analysis of biopsied cells as part of an assisted reproductive procedure. It is generally considered to be divided into 2 categories. Preimplantation genetic diagnosis (PGD) is used to detect a specific inherited disorder and aims to prevent the birth of affected children in couples at high risk of transmitting a disorder. Preimplantation genetic s...

Preimplantation Genetic Testing